Bioengineering the Oxygen-Deprived Tumor Microenvironment Within a Three-Dimensional Platform for Studying Tumor-Immune Interactions

Oxygen deprivation within tumors is one of the most prevalent causes of resilient cancer cell survival and increased immune evasion in breast cancer (BCa).Current in vitro models do not adequately mimic physiological oxygen levels relevant to breast tissue and its tumor-immune interactions.In this study, we propose an approach to engineer a three-d

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Influence and evolution mechanism of different sharpness contact forms to mechanical property of cortical bone by nanoindentation

whelen arges spotlight Based on different damage forms of various contact forms to bone, the mechanical response and mechanism were investigated by nanoindentation under different sharpness contact forms.For the purpose of simulating the different sharpness contact forms, two kinds of indenters were used in experiments and finite elements simulatio

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